Spatially understanding Glaucoma

27/09/2019, 14:00 - 15:00 in MAP/0G/017

Mitchell, Hannah (Queen’s University Belfast)


Abstract:

Glaucoma involves the progressive loss of retinal ganglion cells (RGCs) leading to vision loss and ultimately blindness for which there is presently no cure. Due to the high plasticity of the central nervous system (CNS), typically over 60% of RGCs are lost prior to patients exhibiting symptoms of this condition. This results in a marked delay between the beginning of the glaucoma disease process and patients receiving a diagnosis with treatments designed to slow the rate of visual decline (RGC loss).

With recent advances in adaptive optics, non-invasive single cell visualisation technologies are approaching the clinic. A limitation of these technologies is that they can visualise only a small fraction of the total RGC population (typically a few hundred cells out of a total population of 1.2 million). A better understanding of the spatial distribution of RGCs in the healthy and glaucomotous retina may help clinicians diagnose glaucoma earlier.

This talk will cover spatial data analysis techniques along with the challenges of using these techniques within this biological setting.

Mathematical Sciences Research Centre